Exploring the correlation between 3D spatial dose distribution and toxicity in normal tissue
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چکیده
Radiotherapy efficacy is often limited by normal tissue toxicity. Standard models to estimate Normal Tissue Complication Probability (NTCP), such as Lyman-Kutcher-Burman (LKB), often rely on parameters derived from the dose-volume histograms (DVHs) which consider organs and tissues to be completely homogeneous with equal sub-volume radiation sensitivities. As a result, they neglect any potential variation in radiosensitivity within the organ(s) at risk. Therefore, we adopted an atlas based approach for identifying potentially critical anatomic structures utilizing the full spatial dose distribution [1, 2]. This was achieved by deforming 3D dose distributions from a patient cohort onto a single “Reference Patient” as illustrated in Fig 1.
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